Gastroenterology
Anorectal Therapy

Nitroglycerin Rectal Cream

Topical medication used to treat anal fissures by reducing anal sphincter pressure and improving blood flow; Dispensed in tube with tip.

Dosage Form:
Cream
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How it works

Nitroglycerin releases nitric oxide which relaxes smooth muscle in the internal anal sphincter.

Side Effects

Common side effects include headache, dizziness, flushing, and local irritation.

Storage

Store at room temperature (68–77°F / 20–25°C). Do not refrigerate or freeze.

Pregnancy Information

Use during pregnancy only if clearly needed and directed by a healthcare provider.

Drug Interactions

Do not use with phosphodiesterase-5 inhibitors (such as sildenafil, tadalafil) or other nitrate medications due to risk of severe hypotension.

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