Womens Health
Hormone therapy

Estriol / Tretinoin Cream

Estriol/Tretinoin cream is a compounded topical medication combining a mild estrogen (estriol) and a retinoid (tretinoin) used for skin rejuvenation or menopausal atrophic changes.

Dosage Form:
Cream
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How it works

Estriol improves tissue thickness and hydration by stimulating estrogen receptors, while tretinoin increases cell turnover and collagen production.

Side Effects

May cause redness, peeling, dryness, burning, photosensitivity, and rarely mild hormonal effects.

Storage

Store at room temperature (68–77°F / 20–25°C). Do not refrigerate or freeze.

Pregnancy Information

Not indicated for use during pregnancy.

Drug Interactions

It may interact with other topical irritants (e.g., benzoyl peroxide), photosensitizing agents, and estrogen-containing therapies, potentially increasing irritation or hormonal exposure.

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